The Rare Sugar Tagatose Differentially Inhibits the Growth of Phytophthora infestans and Phytophthora cinnamomi by Interfering With Mitochondrial Processes.
Identifieur interne : 000029 ( Main/Exploration ); précédent : 000028; suivant : 000030The Rare Sugar Tagatose Differentially Inhibits the Growth of Phytophthora infestans and Phytophthora cinnamomi by Interfering With Mitochondrial Processes.
Auteurs : Abdessalem Chahed [Italie, Belgique, France] ; Andrea Nesler [Italie, Belgique] ; Lorella Navazio [Italie] ; Barbara Baldan [Italie] ; Isabella Busato [Italie] ; Essaid Ait Barka [France] ; Ilaria Pertot [Italie] ; Gerardo Puopolo [Italie] ; Michele Perazzolli [Italie]Source :
- Frontiers in microbiology [ 1664-302X ] ; 2020.
Abstract
Rare sugars are monosaccharides with limited availability in nature and their biological functions are largely unknown. Among them, tagatose was developed as a low-calorie sweetener and showed beneficial effects on human health. Tagatose is metabolized by only certain microbial taxa and inhibits the growth of important crop pathogens (e.g., Phytophthora infestans), but its mode of action and the microbial responses are unknown. The aim of this study was to understand the tagatose mode of action against Phytophthora spp., with the final aim of developing new plant protection products. Tagatose inhibited P. infestans growth in vitro and caused severe ultrastructural alterations, with the formation of circular and concentric mitochondrial cristae. Decreased ATP content and reduced oxygen consumption rate (OCR) were found in tagatose-incubated P. infestans as compared to the control, with the consequent accumulation of reactive oxygen species (ROS) and induction of genes related to apoptosis and oxidative stress response. On the other hand, tagatose did not, or only slightly, affect the growth, cellular ultrastructure and mitochondrial processes in Phytophthora cinnamomi, indicating a species-specific response to this rare sugar. The mode of action of tagatose against P. infestans was mainly based on the inhibition of mitochondrial processes and this rare sugar seems to be a promising active substance for the further development of eco-friendly fungicides, thanks to its anti-nutritional properties on some phytopathogens and low risk for human health.
DOI: 10.3389/fmicb.2020.00128
PubMed: 32117150
PubMed Central: PMC7015900
Affiliations:
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Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biological Products for Agriculture (Bi-PA), Londerzeel, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Biological Products for Agriculture (Bi-PA), Londerzeel</wicri:regionArea><wicri:noRegion>Londerzeel</wicri:noRegion></affiliation></author><author><name sortKey="Navazio, Lorella" sort="Navazio, Lorella" uniqKey="Navazio L" first="Lorella" last="Navazio">Lorella Navazio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Padua, Padua, Italy.</nlm:affiliation><country 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xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Ait Barka, Essaid" sort="Ait Barka, Essaid" uniqKey="Ait Barka E" first="Essaid" last="Ait Barka">Essaid Ait Barka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Pertot, Ilaria" sort="Pertot, Ilaria" uniqKey="Pertot I" first="Ilaria" last="Pertot">Ilaria Pertot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation></author><author><name sortKey="Puopolo, Gerardo" sort="Puopolo, Gerardo" uniqKey="Puopolo G" first="Gerardo" last="Puopolo">Gerardo Puopolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation></author><author><name sortKey="Perazzolli, Michele" sort="Perazzolli, Michele" uniqKey="Perazzolli M" 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wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biological Products for Agriculture (Bi-PA), Londerzeel, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Biological Products for Agriculture (Bi-PA), Londerzeel</wicri:regionArea><wicri:noRegion>Londerzeel</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Nesler, Andrea" sort="Nesler, Andrea" uniqKey="Nesler A" first="Andrea" last="Nesler">Andrea Nesler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biological Products for Agriculture (Bi-PA), Londerzeel, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Biological Products for Agriculture (Bi-PA), Londerzeel</wicri:regionArea><wicri:noRegion>Londerzeel</wicri:noRegion></affiliation></author><author><name sortKey="Navazio, Lorella" sort="Navazio, Lorella" uniqKey="Navazio L" first="Lorella" last="Navazio">Lorella Navazio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Botanical Garden, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Botanical Garden, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Baldan, Barbara" sort="Baldan, Barbara" uniqKey="Baldan B" first="Barbara" last="Baldan">Barbara Baldan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Botanical Garden, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Botanical Garden, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Busato, Isabella" sort="Busato, Isabella" uniqKey="Busato I" first="Isabella" last="Busato">Isabella Busato</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Ait Barka, Essaid" sort="Ait Barka, Essaid" uniqKey="Ait Barka E" first="Essaid" last="Ait Barka">Essaid Ait Barka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Pertot, Ilaria" sort="Pertot, Ilaria" uniqKey="Pertot I" first="Ilaria" last="Pertot">Ilaria Pertot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation></author><author><name sortKey="Puopolo, Gerardo" sort="Puopolo, Gerardo" uniqKey="Puopolo G" first="Gerardo" last="Puopolo">Gerardo Puopolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation></author><author><name sortKey="Perazzolli, Michele" sort="Perazzolli, Michele" uniqKey="Perazzolli M" first="Michele" last="Perazzolli">Michele Perazzolli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige</wicri:regionArea><wicri:noRegion>San Michele all'Adige</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in microbiology</title><idno type="ISSN">1664-302X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rare sugars are monosaccharides with limited availability in nature and their biological functions are largely unknown. Among them, tagatose was developed as a low-calorie sweetener and showed beneficial effects on human health. Tagatose is metabolized by only certain microbial taxa and inhibits the growth of important crop pathogens (e.g., <i>Phytophthora infestans</i>), but its mode of action and the microbial responses are unknown. The aim of this study was to understand the tagatose mode of action against <i>Phytophthora</i> spp., with the final aim of developing new plant protection products. Tagatose inhibited <i>P. infestans</i> growth <i>in vitro</i> and caused severe ultrastructural alterations, with the formation of circular and concentric mitochondrial cristae. Decreased ATP content and reduced oxygen consumption rate (OCR) were found in tagatose-incubated <i>P. infestans</i> as compared to the control, with the consequent accumulation of reactive oxygen species (ROS) and induction of genes related to apoptosis and oxidative stress response. On the other hand, tagatose did not, or only slightly, affect the growth, cellular ultrastructure and mitochondrial processes in <i>Phytophthora cinnamomi</i>, indicating a species-specific response to this rare sugar. The mode of action of tagatose against <i>P. infestans</i> was mainly based on the inhibition of mitochondrial processes and this rare sugar seems to be a promising active substance for the further development of eco-friendly fungicides, thanks to its anti-nutritional properties on some phytopathogens and low risk for human health.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32117150</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-302X</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in microbiology</Title><ISOAbbreviation>Front Microbiol</ISOAbbreviation></Journal><ArticleTitle>The Rare Sugar Tagatose Differentially Inhibits the Growth of <i>Phytophthora infestans</i> and <i>Phytophthora cinnamomi</i> by Interfering With Mitochondrial Processes.</ArticleTitle><Pagination><MedlinePgn>128</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fmicb.2020.00128</ELocationID><Abstract><AbstractText>Rare sugars are monosaccharides with limited availability in nature and their biological functions are largely unknown. Among them, tagatose was developed as a low-calorie sweetener and showed beneficial effects on human health. Tagatose is metabolized by only certain microbial taxa and inhibits the growth of important crop pathogens (e.g., <i>Phytophthora infestans</i>), but its mode of action and the microbial responses are unknown. The aim of this study was to understand the tagatose mode of action against <i>Phytophthora</i> spp., with the final aim of developing new plant protection products. Tagatose inhibited <i>P. infestans</i> growth <i>in vitro</i> and caused severe ultrastructural alterations, with the formation of circular and concentric mitochondrial cristae. Decreased ATP content and reduced oxygen consumption rate (OCR) were found in tagatose-incubated <i>P. infestans</i> as compared to the control, with the consequent accumulation of reactive oxygen species (ROS) and induction of genes related to apoptosis and oxidative stress response. On the other hand, tagatose did not, or only slightly, affect the growth, cellular ultrastructure and mitochondrial processes in <i>Phytophthora cinnamomi</i>, indicating a species-specific response to this rare sugar. The mode of action of tagatose against <i>P. infestans</i> was mainly based on the inhibition of mitochondrial processes and this rare sugar seems to be a promising active substance for the further development of eco-friendly fungicides, thanks to its anti-nutritional properties on some phytopathogens and low risk for human health.</AbstractText><CopyrightInformation>Copyright © 2020 Chahed, Nesler, Navazio, Baldan, Busato, Ait Barka, Pertot, Puopolo and Perazzolli.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chahed</LastName><ForeName>Abdessalem</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biological Products for Agriculture (Bi-PA), Londerzeel, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nesler</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biological Products for Agriculture (Bi-PA), Londerzeel, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navazio</LastName><ForeName>Lorella</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Botanical Garden, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baldan</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Botanical Garden, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Busato</LastName><ForeName>Isabella</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biology, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ait Barka</LastName><ForeName>Essaid</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Plant Induced Resistance and Bioprotection, University of Reims Champagne-Ardenne, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pertot</LastName><ForeName>Ilaria</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puopolo</LastName><ForeName>Gerardo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perazzolli</LastName><ForeName>Michele</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Microbiol</MedlineTA><NlmUniqueID>101548977</NlmUniqueID><ISSNLinking>1664-302X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Phytophthora spp.</Keyword><Keyword MajorTopicYN="N">antioomycete activity</Keyword><Keyword MajorTopicYN="N">biological control</Keyword><Keyword MajorTopicYN="N">mitochondrial alteration</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword><Keyword MajorTopicYN="N">rare sugar</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>10</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Chahed</name></noRegion><name sortKey="Nesler, Andrea" sort="Nesler, Andrea" uniqKey="Nesler A" first="Andrea" last="Nesler">Andrea Nesler</name></country><country name="France"><region name="Grand Est"><name sortKey="Chahed, Abdessalem" sort="Chahed, Abdessalem" uniqKey="Chahed A" first="Abdessalem" last="Chahed">Abdessalem Chahed</name></region><name sortKey="Ait Barka, Essaid" sort="Ait Barka, Essaid" uniqKey="Ait Barka E" first="Essaid" last="Ait Barka">Essaid Ait Barka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= The Rare Sugar Tagatose Differentially Inhibits the Growth of Phytophthora infestans and Phytophthora cinnamomi by Interfering With Mitochondrial Processes.
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